Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1200 participants from specialist neurosurgical units. Our goal is to establish which VPS

Site Recruitment
Alder Hey Children's Hospital 83
The Walton Centre 112
Southampton General Hospital 144
Leeds General Infirmary 47
Queens Medical Centre-Nottingham 97
Royal Manchester Children's Hospital 33
Great Ormond Street Hospital 55
Salford Royal Hospital 52
Addenbrookes Hospital 53
Sheffield Children's Hospital 29
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 83
Birmingham Children's Hospital 28
Bristol 133
Kings College Hospital 33
Royal Sick Children's Hospital-Edinburgh 7
Western General Hospital- Edinburgh 5
James Cook Hospital 16
Children's University Hospital Dublin 47
The National Hospital, Queens Square 18
The Royal Victoria Infirmary, Newcastle 8
Total recruitment 1105
Table last updated: 16th May 2016  
provides most protection against infection and to ensure standardisation of care and infection

rates across the country.

Recruitment status


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