Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1600 participants from specialist neurosurgical units. Our goal is to establish which VPS provides most protection against infection and to ensure standardisation of care and infection

rates across the country.

Recruitment status

Site Recruitment
Alder Hey Children's Hospital 103
The Walton Centre 144
Southampton General Hospital 151
Leeds General Infirmary 62
Queens Medical Centre-Nottingham 119
Royal Manchester Children's Hospital 39
Great Ormond Street Hospital 65
Salford Royal Hospital 66
Addenbrookes Hospital 72
Sheffield Children's Hospital 40
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 105
Birmingham Children's Hospital 30
Bristol 156
Kings College Hospital 35
Royal Sick Children's Hospital-Edinburgh 8
Western General Hospital- Edinburgh 5
James Cook Hospital 18
Children's University Hospital Dublin 61
The National Hospital, Queens Square 49
The Royal Victoria Infirmary, Newcastle 14
Total recruitment 1366
Table last updated 29th November 2016  




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