Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1600 participants from specialist neurosurgical units. Our goal is to establish which VPS provides most protection against infection and to ensure standardisation of care and infection

rates across the country




Recruitment status

Site Recruitment
Alder Hey Children's Hospital 119
The Walton Centre 155
Southampton General Hospital 175
Leeds General Infirmary 92
Queens Medical Centre-Nottingham 141
Royal Manchester Children's Hospital 48
Great Ormond Street Hospital 71
Salford Royal Hospital 82
Addenbrookes Hospital 85
Sheffield Children's Hospital 42
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 129

Birmingham Children's Hospital
Bristol 188
Kings College Hospital 36
Royal Sick Children's Hospital-Edinburgh 8
Western General Hospital- Edinburgh 5
James Cook Hospital 22
Children's University Hospital Dublin 69
The National Hospital, Queens Square 73
The Royal Victoria Infirmary, Newcastle 14
Total recruitment 1606
Table last updated 8th February 2018  




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