Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1600 participants from specialist neurosurgical units. Our goal is to establish which VPS provides most protection against infection and to ensure standardisation of care and infection

rates across the country.



Recruitment status

Site Recruitment
Alder Hey Children's Hospital 109
The Walton Centre 147
Southampton General Hospital 154
Leeds General Infirmary 66
Queens Medical Centre-Nottingham 124
Royal Manchester Children's Hospital 41
Great Ormond Street Hospital 65
Salford Royal Hospital 68
Addenbrookes Hospital 75
Sheffield Children's Hospital 42
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 111

Birmingham Children's Hospital
Bristol 163
Kings College Hospital 36
Royal Sick Children's Hospital-Edinburgh 8
Western General Hospital- Edinburgh 5
James Cook Hospital 18
Children's University Hospital Dublin 64
The National Hospital, Queens Square 52
The Royal Victoria Infirmary, Newcastle 14
Total recruitment 1416
Table last updated 23rd Feb 2017  




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