Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1600 participants from specialist neurosurgical units. Our goal is to establish which VPS provides most protection against infection and to ensure standardisation of care and infection

rates across the country.

Recruitment status

Site Recruitment
Alder Hey Children's Hospital 102
The Walton Centre 142
Southampton General Hospital 149
Leeds General Infirmary 63
Queens Medical Centre-Nottingham 115
Royal Manchester Children's Hospital 39
Great Ormond Street Hospital 65
Salford Royal Hospital 65
Addenbrookes Hospital 70
Sheffield Children's Hospital 40
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 101
Birmingham Children's Hospital 30
Bristol 150
Kings College Hospital 34
Royal Sick Children's Hospital-Edinburgh 8
Western General Hospital- Edinburgh 5
James Cook Hospital 18
Children's University Hospital Dublin 59
The National Hospital, Queens Square 45
The Royal Victoria Infirmary, Newcastle 14
Total recruitment 1337
Table last updated 29th November 2016  




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